Please use this identifier to cite or link to this item: https://rsuir-library.rsu.ac.th/handle/123456789/2734
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dc.contributor.advisorChanisa Kiatsurayanon-
dc.contributor.authorPitcharat Pituvong-
dc.date.accessioned2025-01-29T05:59:30Z-
dc.date.available2025-01-29T05:59:30Z-
dc.date.issued2024-
dc.identifier.urihttps://rsuir-library.rsu.ac.th/handle/123456789/2734-
dc.descriptionThesis (M.S. (Dermatology and Dermatosurgery)) -- Rangsit University, 2023en_US
dc.language.isoenen_US
dc.publisherRangsit Universityen_US
dc.subjectPlatelet-rich plasmaen_US
dc.subjectPlasma -- Physiologyen_US
dc.subjectLichen planusen_US
dc.titleThe study of effectiveness of platelet-rich plasma (PRP) treatment for lichen planus pigmentosus (pilot study)en_US
dc.typeThesisen_US
dc.description.other-abstractThis is the first pilot study utilizing intradermal platelet-rich plasma (PRP) in the treatment of lichen planus pigmentosus (LPP). Five participants with a diagnosis was LPP by clinical and histologic features enrolled in these studies. The participants received three sessions of intradermal PRP 2 weeks apart, with a follow up after 2 weeks, 4 weeks, 8 weeks. The melanin index (MI), clinical improvement of pigmentation, patient satisfaction score, and monitored adverse effects were measured. The mean MI score of the subjects was 450.33±69.91 and declined to 392.60±73.88 at the end of study (week 12). All patients demonstrated a significant reduction of the MI score since the first PRP injection (week 2). Clinical improvement as evidenced by escalation of mean QGS grading by 2 dermatologists was initially observed at week 6. The mean patient self-assessment score at week 12 was reported to be thr level of satisfaction, “very satisfied”. Adverse effects were minimal including swelling at injection sites and bruising, which spontaneously resolved in a few days. In summary, intradermal injection of PRP could be an effective alternative or complementary treatment option for treatment-resistant lichen planus pigmentosus. The limitation of our study was the small sample size and short follow-up period.en_US
dc.description.degree-nameMaster of Scienceen_US
dc.description.degree-levelMaster's Degreeen_US
dc.contributor.degree-disciplineDermatology and Dermatosurgeryen_US
Appears in Collections:Med-DD-M-Thesis

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