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Please use this identifier to cite or link to this item: https://rsuir-library.rsu.ac.th/handle/123456789/3210
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dc.contributor.advisorPinnaree Kattipathannapong-
dc.contributor.authorRomaldo Ximenes Amaral Mendes, Amadeu-
dc.date.accessioned2026-02-25T08:38:33Z-
dc.date.available2026-02-25T08:38:33Z-
dc.date.issued2025-
dc.identifier.urihttps://rsuir-library.rsu.ac.th/handle/123456789/3210-
dc.descriptionThesis (M.Sc. (Dermatology and Dermatosurgery)) -- Rangsit University, 2024en_US
dc.language.isoenen_US
dc.publisherRangsit University. Libraryen_US
dc.subjectDermatologyen_US
dc.subjectDermatomyositisen_US
dc.subjectClinical characteristicsen_US
dc.titleClinical characteristics of adult dermatomyositis patients with anti-transcription intermediary factor 1-gamma positiveen_US
dc.typeThesisen_US
dc.description.other-abstractDermatomyositis, an idiopathic inflammatory myopathy, presents with varied clinical manifestations and immune profiles, posing diagnostic and therapeutic challenges. This systematic review examined 11 cohort studies involving 261 adult dermatomyositis (DM) patients with anti-TIF1 γ antibodies. Predominantly female 76.6% with a median onset age of 54.2 years, patients were mostly from Asian ethnicities 77.4%. Median follow-up was 48 months, with a median time from DM diagnosis to cancer development of 4.75 months. The median age at cancer diagnosis was 61.75 years, with a median time from diagnosis to death of 8.3 months. Malignancy was associated with 45.4% of patients. Common cutaneous manifestations included heliotrope rash 78.0% and Gottron's sign 58.1%. Musculoskeletal symptoms comprised proximal muscle weakness at 81.6% and myalgia at 36.2%. Pulmonary involvement occurred in 12.3% of patients. The most frequent malignancies seen in cases of dermatomyositis with anti-TIF1 gamma antibodies include nasopharyngeal 11.8%, lung 11.0%, and breast 10.1% cancers from 119 cases. The mortality rate associated with this condition is noted to be 11.2%. Further research is needed to elucidate underlying pathogenic mechanisms and optimize patient managementen_US
dc.description.degree-nameMaster of Scienceen_US
dc.description.degree-levelMaster's Degreeen_US
dc.contributor.degree-disciplineDermatology and Dermatosurgeryen_US
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