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Please use this identifier to cite or link to this item: https://rsuir-library.rsu.ac.th/handle/123456789/2731
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dc.contributor.advisorPraneet Sajjachareonpong-
dc.contributor.authorPasinee Deeudomwongsa-
dc.date.accessioned2025-01-29T05:52:18Z-
dc.date.available2025-01-29T05:52:18Z-
dc.date.issued2023-
dc.identifier.urihttps://rsuir-library.rsu.ac.th/handle/123456789/2731-
dc.descriptionThesis (M.S. (Dermatology and Dermatosurgery)) -- Rangsit University, 2023en_US
dc.language.isoenen_US
dc.publisherRangsit Universityen_US
dc.subjectPlasma -- Physiologyen_US
dc.subjectPlatelet-rich plasmaen_US
dc.subjectDermatomyositisen_US
dc.titleThe effectiveness of intradermal platelet-rich plasma for the treatment of acquired bilateral nevus of Ota-Like macules Hori s nevus in institute of dermatology Thailand, pilot studyen_US
dc.typeThesisen_US
dc.description.other-abstractHori's nevus is a pigmentation condition that affects many Asian women. Today's treatments aren't all effective. Recent studies have proposed platelet-rich plasma (PRP) for skin pigmentation issues. This study assessed intradermal PRP therapy for Hori's nevus's effectiveness and safety. Ten female patients received bilateral intradermal PRP every two weeks for four time. The modified dermal pigmentation and severity index (mDPASI), mean melanin index, brightening score, and patient self-assessment were evaluated at two-, four-, eight-, and twelve-weeks post-treatment. The safety of treatment was evaluated by monitoring adverse events. At twelve weeks post-treatment, mDPASI improved 38.86% from 0.929 ± 0.617 to 0.568 ± 0.415 (p = 0.003). The mean melanin index fell 12.75% from 208.650 ± 26.319 to 182.052 ± 17.028 (p < 0.0001). In addition, mean brightness score between two experts is 1.4, indicating moderate lightening (>25-50% improvement). At week 12, 20% of the 10 patients reported a significant improvement (25-50% improvement), 50% a marked improvement, and 30% near-normal skin. Side effects included pain, mild edema, and bruising, which spontaneously resolved within day 3. This study reveals PRP may be an effective alternative to standard Hori's nevus treatments. However, larger samples and longer follow-ups are needed to corroborate these results.en_US
dc.description.degree-nameMaster of Scienceen_US
dc.description.degree-levelMaster's Degreeen_US
dc.contributor.degree-disciplineDermatology and Dermatosurgeryen_US
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