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https://rsuir-library.rsu.ac.th/handle/123456789/2731| Title: | The effectiveness of intradermal platelet-rich plasma for the treatment of acquired bilateral nevus of Ota-Like macules Hori s nevus in institute of dermatology Thailand, pilot study |
| Authors: | Pasinee Deeudomwongsa |
| metadata.dc.contributor.advisor: | Praneet Sajjachareonpong |
| Keywords: | Plasma -- Physiology;Platelet-rich plasma;Dermatomyositis |
| Issue Date: | 2023 |
| Publisher: | Rangsit University |
| metadata.dc.description.other-abstract: | Hori's nevus is a pigmentation condition that affects many Asian women. Today's treatments aren't all effective. Recent studies have proposed platelet-rich plasma (PRP) for skin pigmentation issues. This study assessed intradermal PRP therapy for Hori's nevus's effectiveness and safety. Ten female patients received bilateral intradermal PRP every two weeks for four time. The modified dermal pigmentation and severity index (mDPASI), mean melanin index, brightening score, and patient self-assessment were evaluated at two-, four-, eight-, and twelve-weeks post-treatment. The safety of treatment was evaluated by monitoring adverse events. At twelve weeks post-treatment, mDPASI improved 38.86% from 0.929 ± 0.617 to 0.568 ± 0.415 (p = 0.003). The mean melanin index fell 12.75% from 208.650 ± 26.319 to 182.052 ± 17.028 (p < 0.0001). In addition, mean brightness score between two experts is 1.4, indicating moderate lightening (>25-50% improvement). At week 12, 20% of the 10 patients reported a significant improvement (25-50% improvement), 50% a marked improvement, and 30% near-normal skin. Side effects included pain, mild edema, and bruising, which spontaneously resolved within day 3. This study reveals PRP may be an effective alternative to standard Hori's nevus treatments. However, larger samples and longer follow-ups are needed to corroborate these results. |
| Description: | Thesis (M.S. (Dermatology and Dermatosurgery)) -- Rangsit University, 2023 |
| metadata.dc.description.degree-name: | Master of Science |
| metadata.dc.description.degree-level: | Master's Degree |
| metadata.dc.contributor.degree-discipline: | Dermatology and Dermatosurgery |
| URI: | https://rsuir-library.rsu.ac.th/handle/123456789/2731 |
| metadata.dc.type: | Thesis |
| Appears in Collections: | Med-DD-M-Thesis |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| PASINEE DEEUDOMWONGSA.pdf | 1.51 MB | Adobe PDF | View/Open |
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