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https://rsuir-library.rsu.ac.th/handle/123456789/3203| Title: | Remission rate of Pemphigus vulgaris and Pemphigus foliaceus in the institute of dermatology : a 7 years retrospective study |
| Authors: | Araya Sasiwilasakorn |
| metadata.dc.contributor.advisor: | Wanida Limpongsanurak |
| Keywords: | The Institute of Dermatology -- Research;Pemphigus;Dermatology;Prednisolone -- adverse effects |
| Issue Date: | 2024 |
| Publisher: | Rangsit University. Library |
| metadata.dc.description.other-abstract: | Pemphigus, an autoimmune blister disease caused by autoantibodies targeting desmoglein 1 and 3, as well as desmosomal cadherins, is characterized by blistering formation and can be a long-term condition with the possibility of relapse. This study aimed to evaluate the remission rates and compare them between pemphigus vulgaris (PV) and pemphigus foliaceus (PF), together with prognostic factors in the Institution of Dermatology. A retrospective analysis was conducted on 426 patients diagnosed and treated at Institute of Dermatology (a tertiary skin hospital in Bangkok, Thailand) between January 1, 2016, and December 31, 2022, for PV and PF. Patients were followed up for 1, 2, and 5 years to assess complete remission using the consensus statement criteria. The remission rate for PV was 3.3%, 17.5%, and 48.4% at 1, 2, and 5 years after diagnosis respectively. The remission rate of PF was 7.9%, 33.1%, and 61.6% at 1, 2, and 5 years following diagnosis. PF demonstrated significantly higher remission rates compared to PV at all time points (P < .001). The average timing of remission was 60 months for PV (95% confidence interval 58.6-61.3) and 36 months for PF (95% confidence interval 23.1- 48.8). Prognostic factors associated with complete remission include age, age at onset, underlying disease control, disease severity, site of primary involvement and initial mucosal involvement. In conclusion, the remission rates of PV and PF at five years were 48.4% and 61.6% respectively. PF achieves complete remission more frequently than PV. Good control of underlying disease, absence of initial mucosal involvement, and mild severity disease were associated with better prognosis for both PV and PF |
| Description: | Thesis (M.Sc. (Dermatology and Dermatosurgery)) -- Rangsit University, 2024 |
| metadata.dc.description.degree-name: | Master of Science |
| metadata.dc.description.degree-level: | Master's Degree |
| metadata.dc.contributor.degree-discipline: | Dermatology and Dermatosurgery |
| URI: | https://rsuir-library.rsu.ac.th/handle/123456789/3203 |
| metadata.dc.type: | Thesis |
| Appears in Collections: | Med-DD-M-Thesis |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ARAYA SASIWILASAKORN.pdf | 318.19 kB | Adobe PDF | View/Open |
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