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Please use this identifier to cite or link to this item: https://rsuir-library.rsu.ac.th/handle/123456789/3211
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dc.contributor.advisorWanida Pongstaporn-
dc.contributor.advisorAcharawan Thongmee-
dc.contributor.authorThaworn Kongton-
dc.date.accessioned2026-02-25T08:41:59Z-
dc.date.available2026-02-25T08:41:59Z-
dc.date.issued2025-
dc.identifier.urihttps://rsuir-library.rsu.ac.th/handle/123456789/3211-
dc.descriptionThesis (M.Sc. (Biomedical Sciences)) -- Rangsit University, 2024en_US
dc.language.isoenen_US
dc.publisherRangsit University. Libraryen_US
dc.subjectBreast -- Canceren_US
dc.subjectCancer -- Etiologyen_US
dc.subjectBreast -- Cancer -- Imagingen_US
dc.titlePolymorphism of mir34 b/c in Thai breast cancer patientsen_US
dc.typeThesisen_US
dc.description.other-abstractMiR-34b/c plays a critical role in various aspects of carcinogenesis. Notably, the pri-miR34b/c (rs4938723) T>C polymorphism has been identified as significant biomarker in several types of cancers. The objective of this study was to investigate whether the pri-miR34b/c (rs4938723) T>C polymorphism is associated with breast cancer susceptibility. In addition, the study examined the relationship between this polymorphism and clinicopathologic features, including survival outcomes, in Thai breast cancer patients. DNA samples were extracted from the blood of 100 Thai breast cancer patients and 100 healthy Thai women. Genotyping of the pri-miR34b/c (rs4938723) T>C polymorphism was performed using polymerase chain reactionrestriction fragment length polymorphism (PCR - RFLP) analysis. The results showed no statistically significant difference in the distribution of pri-miR34b/c (rs4938723) T>C genotypes between breast cancer patients and healthy controls. This finding suggests no association between this polymorphism and breast cancer susceptibility or clinicopathologic characteristics. However, certain clinical factors specifically age greater than 50 and histologic grade III were identified as significant prognostic indicators for survival, with p-values of 0.017 and 0.010, respectivelyen_US
dc.description.degree-nameMaster of Scienceen_US
dc.description.degree-levelMaster's Degreeen_US
dc.contributor.degree-disciplineBiomedical Sciencesen_US
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