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https://rsuir-library.rsu.ac.th/handle/123456789/2734| Title: | The study of effectiveness of platelet-rich plasma (PRP) treatment for lichen planus pigmentosus (pilot study) |
| Authors: | Pitcharat Pituvong |
| metadata.dc.contributor.advisor: | Chanisa Kiatsurayanon |
| Keywords: | Platelet-rich plasma;Plasma -- Physiology;Lichen planus |
| Issue Date: | 2024 |
| Publisher: | Rangsit University |
| metadata.dc.description.other-abstract: | This is the first pilot study utilizing intradermal platelet-rich plasma (PRP) in the treatment of lichen planus pigmentosus (LPP). Five participants with a diagnosis was LPP by clinical and histologic features enrolled in these studies. The participants received three sessions of intradermal PRP 2 weeks apart, with a follow up after 2 weeks, 4 weeks, 8 weeks. The melanin index (MI), clinical improvement of pigmentation, patient satisfaction score, and monitored adverse effects were measured. The mean MI score of the subjects was 450.33±69.91 and declined to 392.60±73.88 at the end of study (week 12). All patients demonstrated a significant reduction of the MI score since the first PRP injection (week 2). Clinical improvement as evidenced by escalation of mean QGS grading by 2 dermatologists was initially observed at week 6. The mean patient self-assessment score at week 12 was reported to be thr level of satisfaction, “very satisfied”. Adverse effects were minimal including swelling at injection sites and bruising, which spontaneously resolved in a few days. In summary, intradermal injection of PRP could be an effective alternative or complementary treatment option for treatment-resistant lichen planus pigmentosus. The limitation of our study was the small sample size and short follow-up period. |
| Description: | Thesis (M.S. (Dermatology and Dermatosurgery)) -- Rangsit University, 2023 |
| metadata.dc.description.degree-name: | Master of Science |
| metadata.dc.description.degree-level: | Master's Degree |
| metadata.dc.contributor.degree-discipline: | Dermatology and Dermatosurgery |
| URI: | https://rsuir-library.rsu.ac.th/handle/123456789/2734 |
| metadata.dc.type: | Thesis |
| Appears in Collections: | Med-DD-M-Thesis |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| PITCHARAT PITUVONG.pdf | 745.4 kB | Adobe PDF | View/Open |
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