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https://rsuir-library.rsu.ac.th/handle/123456789/3210| Title: | Clinical characteristics of adult dermatomyositis patients with anti-transcription intermediary factor 1-gamma positive |
| Authors: | Romaldo Ximenes Amaral Mendes, Amadeu |
| metadata.dc.contributor.advisor: | Pinnaree Kattipathannapong |
| Keywords: | Dermatology;Dermatomyositis;Clinical characteristics |
| Issue Date: | 2025 |
| Publisher: | Rangsit University. Library |
| metadata.dc.description.other-abstract: | Dermatomyositis, an idiopathic inflammatory myopathy, presents with varied clinical manifestations and immune profiles, posing diagnostic and therapeutic challenges. This systematic review examined 11 cohort studies involving 261 adult dermatomyositis (DM) patients with anti-TIF1 γ antibodies. Predominantly female 76.6% with a median onset age of 54.2 years, patients were mostly from Asian ethnicities 77.4%. Median follow-up was 48 months, with a median time from DM diagnosis to cancer development of 4.75 months. The median age at cancer diagnosis was 61.75 years, with a median time from diagnosis to death of 8.3 months. Malignancy was associated with 45.4% of patients. Common cutaneous manifestations included heliotrope rash 78.0% and Gottron's sign 58.1%. Musculoskeletal symptoms comprised proximal muscle weakness at 81.6% and myalgia at 36.2%. Pulmonary involvement occurred in 12.3% of patients. The most frequent malignancies seen in cases of dermatomyositis with anti-TIF1 gamma antibodies include nasopharyngeal 11.8%, lung 11.0%, and breast 10.1% cancers from 119 cases. The mortality rate associated with this condition is noted to be 11.2%. Further research is needed to elucidate underlying pathogenic mechanisms and optimize patient management |
| Description: | Thesis (M.Sc. (Dermatology and Dermatosurgery)) -- Rangsit University, 2024 |
| metadata.dc.description.degree-name: | Master of Science |
| metadata.dc.description.degree-level: | Master's Degree |
| metadata.dc.contributor.degree-discipline: | Dermatology and Dermatosurgery |
| URI: | https://rsuir-library.rsu.ac.th/handle/123456789/3210 |
| metadata.dc.type: | Thesis |
| Appears in Collections: | Med-DD-M-Thesis |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| AMADEU ROMALDO XIMENES AMARAL MENDES.pdf | 530.63 kB | Adobe PDF | View/Open |
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